Journal article
In vivo age dependency of unfractionated heparin in infants and children
F Newall, V Ignjatovic, R Summerhayes, A Gan, W Butt, L Johnston, P Monagle
Thrombosis Research | Published : 2009
Abstract
Introduction: Unfractionated Heparin (UFH) is used widely in paediatrics. Paediatric specific recommendations for UFH therapy are few, with the majority of recommendations being extrapolated from adult practice. In vitro studies have shown that this practice may be suboptimal. This study aimed to improve the understanding of the impact of age upon UFH response in vivo. Materials and Methods: This prospective, observational study, conducted in the Paediatric Intensive Care Unit (PICU), included: patients 16 years or younger; treated with UFH of at least 10 U/Kg/hr. Laboratory analysis included: Antithrombin, APTT, Anti-Xa, Anti-IIa and thrombin generation expressed as the Endogenous Thrombin ..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors acknowledge assistance of the members of the Paediatric Intensive Care Unit of the Royal Children's Hospital (RCH), Melbourne, for facilitation of patient identification and collection of clinical data. The support of the RCH Core Laboratory staff in processing the specimens is also acknowledged. This project was supported by an NHMRC Research Grant #454385. Dr Ignjatovic is supported by the Sanofi-Aventis Clinical Research Fellowship. Fiona Newall holds an Australian Postgraduate Award.